Immunomodulatory compounds

A method of immunomodulation in humans and non-human primates, comprising administration to a subject in need of such treatment an immunomodulatory effective dose of a compound of formula (I) or a pharmaceutically or veterinarily acceptable salt thereof:

• wherein
• R1 and R3 independently represent H;
• F;
• Cl;
• Br;
• —NO2;
• —CN;
• C1-C6 alkyl optionally substituted by F or Cl;
• or C1-C6 alkoxy optionally substituted by F;
• R2 represents H, or optionally substituted C1-C6 alkyl, C1-C7 cycloalkyl or optionally substituted phenyl;
• Y represents —O—, —S—, N-oxide, or —N(R5)— wherein R5 represents H or C1-C6 alkyl;
• X represents a bond or a divalent C1-C6 alkylene radical;
• R4 represents —C(═O)NR6NR7, —NR7C(═O)R6, —NR7C(═O)OR6, —NHC(═O)NHR6 or —NHC(═S)NHR6 wherein
• R6 represents H, or a radical of formula -(Alk)b-O wherein b is 0 or 1 and
• Alk is an optionally substituted divalent straight chain or branched C1-C12 alkylene, C2-C12 alkenylene or C2-C12 alkynylene radical which may be interrupted by one or more non-adjacent —O—, —S— or —N(R8)— radicals wherein R8 represents H or C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, or C3-C6 cycloalkyl, and
• Q represents H;
• —CF3;
• —OH;
• —SH;
• —NR8R8 wherein each R8 may be the same or different;
• an ester group;
• or an optionally substituted phenyl, C3-C7 cycloalkyl, C5-C7 cycloalkenyl or heterocyclic ring having from 5 to 8 ring atoms;
• and
• R7 represents H or C1-C6 alkyl;
• or when taken together with the atom or atoms to which they are attached R6 and R7 form an optionally substituted heterocyclic ring having from 5 to 8 ring atoms.