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US 2006/0217409 A1Published application
Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
AssigneeAMR Technology, Inc.
InventorsJames Beck, Anthony Pechulis, Arthur Harms
Life of this patent
Estimating the term…
Abstract
Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.
Claims8
A compound of Formula (50):
- or a pharmaceutically acceptable salt form thereof, wherein R3 is H, R4 is H, R5 is H and R6 is H.
A compound of Formula (60):
- or a pharmaceutically acceptable salt form thereof selected from the group consisting of:
- a compound of Formula (60) wherein R3is H, R4 is H, R5is H and R6 is H and R13 is H;
- a compound of Formula (60) wherein R3 is H, R4 is H, R5is H, R6is H and R13 is Me;
- a compound of Formula (60) wherein R3 is H, R4 is H, R5is H, R6 is H and R13 is Et;
- a compound of Formula (60) wherein R3 is H, R4 is H, R5 is F, R6 is F and R13 is H;
- a compound of Formula (60) wherein R3 is H, R4 is H, R5 is F, R6 is F and R13is Me;
- a compound of Formula (60) wherein R3 is H, R4 is F, R5 is H, R6 is F and R13 is H;
- a compound of Formula (60) wherein R3 is H, R4 is F, R5 is H, R6is F and R13 is Me;
- a compound of Formula (60) wherein R3 is H, R4 is Cl, R5 is H, R6 is H and R13 is H;
- a compound of Formula (60) wherein R3 is H, R4 is Cl, R5 is H, R6 is H and R13 is Me;
- a compound of Formula (60) wherein R3 is H, R4 is F, R5 is H, R6 is H and R13is H;
- a compound of Formula (60) wherein R3 is H, R4 is H, R5 is F, R6 is H and R13 is H;
- a compound of Formula (60) wherein R3 is H, R4 is F, R5 is Cl, R6 is H and R13 is H;
- a compound of Formula (60) wherein R3 is H, R4 is F, R5 is Cl, R6 is H and R13 is Me;
- a compound of Formula (60) wherein R is H, R4 is Cl, R5 is F, R is H and R13 is H;
- and
- a compound of Formula (60) wherein R3 is H, R4 is Cl, R5 is F, R6 is H and R13is Me.
14 more elements
A compound of Formula (70):
- or a pharmaceutically acceptable salt form thereof selected from the group consisting of:
- a compound of Formula (70) wherein R3 is H, R4 is H, R5 is H, R6 is H and R13is H;
- a compound of Formula (70) wherein R3 is H, R4 is H, R5 is H, R6 is H and R13 is Me;
- a compound of Formula (70) wherein R3 is H, R4 is H, R5 is H, R6 is H and R13is Et;
- a compound of Formula (70) wherein R3 is H, R4 is H, R5 is H, R6 is H and R13 is Bn;
- a compound of Formula (70) wherein R3 is H, R4 is H, R5 is F, R6 is F and R13is H;
- a compound of Formula (70) wherein R3 is H, R4 is H, R5 is F, R6 is F and R13 is Me;
- a compound of Formula (70) wherein R3 is H, R4 is F, R5 is H, R6 is F and R13 is Me;
- a compound of Formula (70) wherein R3 is H, R4 is Cl, R5 is H, R6 is H and R13 is H;
- a compound of Formula (70) wherein R3is H, R4 is Cl, R5 is H, R6 is H and R13 is Me;
- a compound of Formula (70) wherein R3 is H, R4 is F, R5 is H, R6 is H and R13 is H;
- a compound of Formula (70) wherein R3 is H, R4 is F, R5 is H, R6 is H and R13is Me;
- a compound of Formula (70) wherein R3 is H, R4 is H, R5 is F, R6 is H and R13 is H;
- a compound of Formula (70) wherein R3 is H, R4 is F, R5 is Cl, R6 is H and R13 is H;
- a compound of Formula (70) wherein R3is H, R4 is F, R5 is Cl, R6 is H and R13 is Me;
- a compound of Formula (70) wherein R3 is H, R4 is Cl, R5 is F, R6 is H and R13 is H;
- and
- a compound of Formula (70) wherein R3 is H, R4 is Cl, R5 is F, R6 is H and R13 is Me.
15 more elements
A compound of Formula (100):
- or a pharmaceutically acceptable salt form thereof, wherein R4is H, R5 is H, R6 is H and R13 is H.
A compound of Formula (130):
- or a pharmaceutically acceptable salt form thereof selected from the group consisting of:
- a compound of Formula (130) wherein R4 is H, R5 is H and is R6 is H;
- and
- a compound of Formula (130) wherein R4is H, R5is Bn and R6 is H.
1 more element
A compound of Formula (160):
- or a pharmaceutically acceptable salt form thereof, wherein R4 is H, R5 is H and R6 is H.
A compound of Formula (190):
- or a pharmaceutically acceptable salt form thereof, wherein R4 is H, R5is H and R6 is H.
A compound of Formula (200):
- or a pharmaceutically acceptable salt form thereof selected from the group consisting of:
- a compound of Formula (200) wherein R4 is H, R5 is H, R6is H and R13 is H;
- and
- a compound of Formula (200) wherein R4 is H, R5 is H, R6is H and R13 is Me.
1 more element
Dependencies are inferred from the claim text.