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US 2006/0217408 A1Published application
Preparation of cabergoline
AssigneeResolution Chemicals Limited
InventorsAlan Greenwood, Derek McHattie, Parveen Bhatarah, Mahmoud Aloui
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AssigneeResolution Chemicals Limited
InventorsAlan Greenwood, Derek McHattie, Parveen Bhatarah, Mahmoud Aloui
Estimating the term…
A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and a p-disubstituted benzene of formula (A) or 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a method for preparing cabergoline Form I comprising dissolving cabergoline in p-disubstituted benzene or 1,3,5-trimethylbenzene and recovering the cabergoline Form I polymorph, suitably by direct crystallization of Form I or by recovery of a solvate which can be converted to Form I. Another aspect of the present invention provides a novel cabergoline polymorph designated cabergoline Form FB and a method of preparing said polymorph by dissolving or forming a solvate of cabergoline in fluorobenzene and recovering cabergoline Form FB.
A method of preparing cabergoline Form I, comprising:
A solvate of cabergoline comprising cabergoline and a p-disubstituted benzene of formula (A)
A method of preparing cabergoline Form I comprising dissolving cabergoline in a solvent comprising a p-disubstituted benzene of formula (A)
A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate.
A solvate of cabergoline comprising cabergoline and 1,3,5-trimethylbenzene.
A method of preparing cabergoline Form I comprising dissolving cabergoline in a solvent including 1,3,5-trimethylbenzene to form a solution and obtaining cabergoline Form I from the solution.
Cabergoline Form FB.
A method of preparing cabergoline Form FB, comprising dissolving cabergoline in a solvent of fluorobenzene to form a solution and obtaining cabergoline Form FB from that solution.
A method of preparing cabergoline Form FB, comprising forming a solvate of cabergoline and fluorobenzene and obtaining cabergoline FB from the solvate.
Dependencies are inferred from the claim text.