US 2006/0217404 A1 · Pyridylpyrimidine derivatives as effective compounds against prion infections and prion diseases

Abstract

The present invention relates to pyridylpyrimidine derivatives of the general formula (I): wherein R represents hydrogen or methyl and Z represents nitrogen containing functional groups, the use of the pyridylpyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of prion infections and prion diseases, as well as compositions containing at least one pyridylpyrimidine derivative and/or pharmaceutically acceptable salt thereof. Furthermore, the present invention is directed to methods for preventing and/or treating prion infections and prion diseases using said pyridylpyrimidine derivatives. Human cellular protein kinases, phosphatases and cellular signal transduction molecules are disclosed as targets for detecting, preventing and/or treating prion infections and diseases, especially BSE, vCJD, or CJD which can be inhibited by the inventive pyridylpyrimidine derivatives.

Claims25

Dependent claims

A compound having the general formula (I):

wherein:
R represents hydrogen or methyl;
Z represents —NO2, —NH2, —NH—CO—X, —NH—CS—X, —NH—CO—NH—X, —NH—SO2—X;
X represents thiophenyl, cyclohexyl, isoquinolinyl, naphthyl, quinolinyl, cyclopentyl, pyridinyl, naphthyridinyl, or
Y, Y′, Y″ are independently of each other —H, —F, —Cl, —Br, —I, —CH2F, —CH2Cl, —CH2Br, —CH2l, —OH, —OCH3, —CH3, —CN, —OCF3, 4-methylpiperazin-1-yl-methyl, —C(CH3)═N—NH—C(NH)—NH2;
and pharmaceutically acceptable salts thereof.

3 more elements

Dependencies are inferred from the claim text.

Pyridylpyrimidine derivatives as effective compounds against prion infections and prion diseases

Life of this patent

Pyridylpyrimidine derivatives as effective compounds against prion infections and prion diseases

Life of this patent

Abstract

Claims25