Substituted 2-aminoacetamides and the use thereof

A compound of Formula II:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1, R2, R3 and R4 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl;
• R5, R6 and R7 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl;
• or R5 is defined as above, and R6 and R7 together with the nitrogen atom to which they are attached form a heterocycle;
• A1 and A2 are independently aryl, heteroaryl, saturated or partially unsaturated carbocyclic, or saturated or partially unsaturated heterocyclic, any of which is optionally substituted,
• provided that at least one of A1 and A2 is other than aryl or saturated or partially unsaturated carbocyclic;
• X is one of O, S, NR8, CH2, NR8C(O), C(O)NR8, SO, SO2 or a covalent bond, where
• R8 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl;
• and
• n is 0, 1, 2 or 3.

A compound selected from the group consisting of:

• 2-(4-(4-tetrahydropyranoxy)benzylamino)-2-methyl-propanamide;
• 2-(4-(1-methyl-4-piperidinoxy)benzylamino)-2-methyl-propanamide;
• 2-(3-(4-fluorophenoxy)-5-pyridylmethylamino)-2-methyl-propanamide;
• 2-(4-(4-pyridinoxy)benzylamino)-2-methyl-propanamide;
• 2-(4-(2-pyrimidinoxy)benzylamino)-2-methyl-propanamide;
• 2-(4-(6-quinolinoxy)benzylamino)-2-methyl-propanamide;
• and
• pharmaceutically acceptable salts thereof.