Cycloalkl, aryl and heteroaryl amino isothiazoles for the treatment of Hepatitis C virus

A compound of Formula I or a salt thereof

• where Q is CN, NHCONRaRb, or CONRaRb, where Ra is C1-C3 alkyl or C1-C3 alkenyl, said alkyl and said alkenyl groups optionally substituted with, independently, 1, 2, or 3 halogen atoms, O—C1-2alkyl, C1-C3 alkenyl, and N(H)C1-2 alkyl, Rb is H or C1-C3 alkyl;
• or Ra and Rb, together with the atoms to which they are attached, form a 5- or 6-membered ring, optionally containing one or two ring double bonds, and optionally containing one ring oxygen atom or one additional ring nitrogen atom;
• and R1 is cyclohexyl, adamantan-1-yl, indan-1-yl, Ar1(CH2)n, or Ar2, where n is zero or 1, Ar1 is
• where X is C—R4 or N, Y is C—R5 or N, and Z is CH or N, provided that Ar contains no more than two ring nitrogen atoms;
• R2, R3, R4, and R5 are, independently, H, F, Cl, Br, I, OH, CN, CF3, NO2, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, C5-C6 cycloalkenyl, O—C1-C6 alkyl, O—C2-C6 alkenyl, C1-C6 alkyl-C(═O)—, C1-C6 alkyl-O—C(═O)—, C1-C6 alkenyl-O—C(═O)—, C1-C6 alkyl-C(═O)O—, C1-C6 alkenyl-C(═O)O, isothiazolyl, isoxazolyl, isoxazolinyl, isoxazolidinyl, oxazolyl, oxazolinyl, oxazolidinyl, thiazolyl, thienyl, furyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, thiazolinyl, thiazolidinyl, isothiazolinyl, isothiazolidinyl, imidazolinyl, imidazolyl, pyridyl, piperidinyl, phenyl, CH3SO2—, NH2SO2—, CH3NHSO2—, CH3SO2NH—, R6R7N—, R6R7NCH2—, R7C(═O)NH, or R6R7NC(═O), wherein R6 and R7 are, independently, H, C1-C4 alkyl, C2-C6 alkenyl;
• R8—C≡C—, wherein R8 is H, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, C5-C6 cycloalkenyl, (CH3)2NCH2—, (CH3)2NCH2CH2—, or phenyl;
• wherein all alkyl, cycloalkyl, alkenyl, and cycloalkenyl groups in Ra-Rb and R2-R8 are optionally substituted with one, two, or three halogen atoms, one C1-C3 alkyl group, or one hydroxyl group;
• and all aryl and heteroaryl groups in Ra-Rb and R2-R8 are optionally substituted with one hydroxy group and with one, two, or three groups selected from F, Cl, Br, I, and C1-C4 alkyl, provided that when n is zero and Ar is phenyl, then 1) R2 is either H or halogen;
• and 2) at least one of R2, R3, R4, and R5 is neither H not C;
• and further provided that Ar is not 4-chloro-3-trichloromethyl-phenyl;
• and Ar2 is
• wherein V is N or CR2, W is N or CR3, X is N or CR4, Y is N or CR5, and Z is N or CH, provided that exactly two of V, W, X, Y, and Z are N, and further provided that the two ring nitrogen atoms are not adjacent, and R2-R5 are, independently, H, F, Cl, Br, I, OH, CN, CF3, NO2, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, C5-C6 cycloalkenyl, C5-C6 cycloalkadienyl, O—C1-C6 alkyl, O—C2-C6 alkenyl, C1-C6 alkyl-C(═O)—, C1-C6 alkyl-O—C(═O)—, C1-C6 alkenyl-O—C(═O)—, C1-C6 alkyl-C(═O)O—, C1-C6 alkenyl-C(═O)O, isothiazolyl, isoxazolyl, isoxazolinyl, isoxazolidinyl, oxazolyl, oxazolinyl, oxazolidinyl, thiazolyl, thienyl, furyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, thiazolinyl, thiazolidinyl, isothiazolinyl, isothiazolidinyl, imidazolinyl, imidazolyl, pyridyl, piperidinyl, phenyl, CH3SO2—, NH2SO2—, CH3NHSO2—, CH3SO2NH—, R6R7N—, R6R7NCH2—, R7C(═O)NH, or R6R7NC(═O), wherein R6 and R7 are, independently, H, C1-C4 alkyl, C2-C6 alkenyl;
• R8—C≡C—, wherein R8 is H, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, C5-C6 cycloalkenyl, (CH3)2NCH2—, (CH3)2NCH2CH2—, or phenyl;
• wherein all alkyl, cycloalkyl, alkenyl, and cycloalkenyl groups in R2-R5 and R6-R8 are optionally substituted with one, two, or three halogen atoms, one C1-C3 alkyl group, or one hydroxyl group;
• and all aryl and heteroaryl groups in R2-R5 and R6-R8 are optionally substituted with one, two, or three groups selected from F, Cl, Br, I, and C1-C4 alkyl;
• Ra is H, C1-C3 alkyl or C1-C3 alkenyl, optionally substituted with O—C1-2 alkyl, C1-C3 alkenyl, or N(H)C1-2 alkyl;
• and Rb is C1-C3 alkyl, or Ra and Rb, together with the atoms to which they are attached, form a 5- or 6-membered ring, optionally containing one or two ring double bonds, and optionally containing one ring oxygen atom or one additional ring nitrogen atom.