Phthalazine derivatives for treating inflammatory diseases

A method of treating leukemias comprising administering a compound of formula I,

• wherein
• r is 0 to 2,
• n is 0 to 3
• R1 and R2
• a) are independently in each case a lower alkyl;
• b) together form a bridge of subformula I*,
• wherein the bond is achieved via the two terminal C atoms and
• m is 0 to 4, or
• c) together form a bridge of subformula I**,
• wherein one or two of the ring members T1, T2, T3 and T4 are nitrogen, and the others are in each case CH, and the bond is achieved via atoms T1 and T4;
• G is —C(═O)—, —CHF—, —CF2—, lower alkylene, C2-C6alkenylene, lower alkylene or C3-C6alkenylene substituted by acyloxy or hydroxy, —CH2—O—, —CH2—S—, —CH2—NH—, —CH2—O—CH2—, —CH2—S—CH2—, —CH2—NH—CH2—, oxa (—O—), thia (—S—), imino (—NH—), —CH2—O—CH2—, —CH2—S—CH2— or
• —CH2—NH—CH2—;
• A, B, D, E and T are independently N or CH subject to the proviso that at least one and not more than three of these radicals are N;
• Q is lower alkyl, lower alkoxy or halogen;
• Ra and Ra′ are each independently H or lower alkyl;
• X is imino, oxa, or thia;
• Y is hydrogen, aryl, heteroaryl, or unsubstituted or substituted cycloalkyl;
• and
• Z is mono- or disubstituted amino, halogen, alkyl, substituted alkyl, hydroxy, etherified or esterified hydroxy, nitro, cyano, carboxy, esterified carboxy, alkanoyl, carbamoyl, N- mono- or N,N-disubstituted carbamoyl, amidino, guanidino, mercapto, sulfo, phenylthio, phenyl lower alkylthio, alkylphenylthio, phenylsulfinyl, phenyl-lower alkylsulfinyl, alkylphenylsulfinyl, phenylsulfonyl, phenyl-lower alkylsulfonyl, alkylphenylsulfonyl, or (alternatively or, in a broader aspect of the invention, in addition) selected from the group consisting of ureido, halo-lower alkylthio, halo-lower alkansulfonyl, pyrazolyl, lower-alkyl pyrazolyl and C2-C7alkenyl;
• wherein—if more than 1 radical Z (m≧2) is present—the substituents Z are selected independently from each other;
• and wherein the bonds characterized in subformula I* by a wavy line are either single or double bonds;
• or an N-oxide of said compound, wherein 1 or more N atoms carry an oxygen atom;
• or a pharmaceutically acceptable salt thereof.