Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines

A salt of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine corresponding to formula I:

• wherein
• R1 is tert-butyl;
• 1,1,3,3-tetramethylbutyl;
• (CH2)nCN where n=4, 5 or 6;
• optionally substituted phenyl;
• C4-C8 cycloalkyl;
• CH2CH2R where R=4-morpholino;
• or CH2Ra,
• wherein Ra represents hydrogen;
• straight or branched C1-C8 alkyl;
• optionally substituted phenyl;
• CO(OR′) where R′=straight or branched C1-C8 alkyl;
• PO(OR″)2 where R″=straight or branched C1-C4 alkyl;
• or Si(RxRyRz) where Rx, Ry, and Rz each independently is straight or branched C1-C4 alkyl, C4-C8 cycloakyl or phenyl,
• R2 is hydrogen;
• CORb, wherein Rb is straight or branched C1-C8 alkyl;
• straight or branched C1-C8 alkoxy;
• C3-C8 cycloalkyl;
• CH2CH2CO(OR′) where R′=straight or branched C1-C4 alkyl;
• adamantyl;
• optionally substituted phenyl;
• benzyloxy;
• optionally substituted 1-naphthyl or 2-naphthyl or respectively optionally substituted 2-pyridyl, 3-pyridyl, 4-pyridyl, thiazolyl or furyl;
• CH2Rc, wherein Rc is hydrogen, straight or branched C1-C8 alkyl or optionally substituted phenyl;
• CH2CH2Rd, wherein Rd is optionally substituted phenyl;
• or CONHRe,
• wherein Re is branched or straight C1-C8 alkyl;
• aryl;
• heteroaryl;
• C3-C8 cycloalkyl or an aryl bound via a C1-C3 alkylene group, heteroaryl or C3-C8 cycloalkyl radical,
• R3 is straight or branched C1-C8 alkyl;
• C3-C8 cycloalkyl;
• optionally substituted phenyl;
• optionally substituted 1-naphthyl;
• 2-naphthyl;
• quinoline;
• anthracene;
• phenanthrene;
• benzothiophene;
• benzofurfuryl;
• optionally substituted pyrrole;
• 2-, 3- or 4-pyridyl;
• optionally substituted furfuryl;
• or optionally substituted thiophene,
• A is a three-membered ring fragment of the formula:
• wherein R4, R6 and R7 each independently is hydrogen;
• straight or branched C1-C8 alkyl;
• fluorine;
• chlorine;
• bromine;
• CF3;
• CN;
• NO2;
• NHRf,
• wherein Rf represents hydrogen;
• straight or branched C1-C8 alkyl;
• or
• COR′″ wherein R′″=straight or branched C1-C4 alkyl or optionally substituted phenyl;
• SRg,
• wherein Rg represents hydrogen, straight or branched C1-C4 alkyl,
• optionally substituted phenyl, optionally substituted pyridine,
• optionally substituted benzyl, or optionally substituted fluorenyl;
• ORh,
• wherein Rh represents hydrogen;
• straight or branched C1-C8 alkyl;
• COR′″ where R′″=straight or branched C1-C4 alkyl or optionally substituted phenyl;
• or CO(OR′) wherein R′=straight or branched C1-C8 alkyl;
• CO(ORi) or CH2CO(ORi), wherein Ri is branched or straight C1-C8 alkyl, or optionally substituted phenyl;
• or
• R6 and R7 together represent a ring fragment —CRi═CRj—CH═CH—, wherein Ri and Rj each represents hydrogen, or one of Ri and Rj is not hydrogen and represents F, Cl, Br, I or straight or branched C1-C8 alkyl, whereas R4 independently thereof has the meaning given above,
• R8 is branched or straight C1-C8 alkyl;
• aryl, heteroaryl;
• C3-C8 cycloalkyl;
• or an aryl bound by a C1-C3 alkylene group, heteroaryl or C3-C8 cycloalkyl group, and
• X represents an anion of an inorganic or organic acid.