Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same
AssigneeBayer HealthCare LLC
InventorsUlrich Rosentreter, Thomas Kramer, Mitsuyuki Shimada, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Kerstin Henninger, Johannes-Peter Stasch, Ralf Wischnat
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Abstract
Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
Claims17
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A method for the treatment of disorders of the urogenital region and cancer comprising administering to a patient in need thereof an effective amount of a compound of formula (I)
- in which
- n represents a number 2, 3 or 4,
- R1 represents hydrogen or (C1-C4)-alkyl
- and
- R2 represents pyridyl or thiazolyl which for its part may be substituted by (C1-C4)-alkyl, halogen, amino, dimethylamino, acetylamino, guanidino, pyridylamino, thienyl, furyl, imidazolyl, pyridyl, morpholinyl, thiomorpholinyl, piperdinyl, piperazinyl, N—(C1-C4)-alkylpiperazinyl, pyrrolidinyl, oxazolyl, isoxazolyl, pyrimidinyl, pyrazinyl, optionally (C1-C4)-alkyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by halogen, (C1-C4)-alkyl or (C1-C4)-alkoxy,
- or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.
A method for the treatment of inflammatory and neuroinflammatory disorders, neurodegenerative disorders and pain comprising administering to a patient in need thereof an effective amount of a compound of formula (I)
- in which
- n represents a number 2, 3 or 4,
- R1 represents hydrogen or (C1-C4)-alkyl
- and
- R2 represents pyridyl or thiazolyl which for its part may be substituted by (C1-C4)-alkyl, halogen, amino, dimethylamino, acetylamino, guanidino, pyridylamino, thienyl, furyl, imidazolyl, pyridyl, morpholinyl, thiomorpholinyl, piperidinyl, piperazinyl, N—(C1-C4)-alkylpiperazinyl, pyrrolidinyl, oxazolyl, isoxazolyl, pyrimidinyl, pyrazinyl, optionally (C1-C4)-alkyl-substituted thiazolyl or phenyl which is optionally substituted up to three times by halogen, (C1-C4)-alkyl or (C1-C4)-alkoxy,
- or a pharmaceutically acceptable salt, hydrate, hydrate of a salt, or solvate thereof.
Dependencies are inferred from the claim text.