Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors

A compound of formula I

• wherein
• Z, Y, X and W represent independently a nitrogen atom or a —CH— group;
• at least two of the Z, Y, X and W represent a —CH— group;
• V represents a bond;
• —(CH2)r—;
• -A-(CH2)s—;
• —CH2-A-(CH2)t—;
• —(CH2)s-A-;
• —(CH2)2-A-(CH2)u—;
• -A-(CH2)v—B—;
• —CH2—CH2—CH2-A-CH2—;
• -A-CH2—CH2—B—CH2—;
• —CH2-A-CH2—CH2—B—;
• —CH2—CH2—CH2-A-CH2—CH2—;
• —CH2—CH2—CH2—CH2-A-CH2—;
• -A-CH2—CH2—B—CH2—CH2—;
• —CH2-A-CH2—CH2—B—CH2—;
• —CH2-A-CH2—CH2—CH2—B—;
• or —CH2—CH2-A-CH2—CH2—B—;
• A and B independently represent —O—;
• —S—;
• —SO—;
• —SO2—;
• U represents aryl;
• heteroaryl;
• T represents —CONR1—;
• —(CH2)pOCO—;
• —(CH2)pN(R1)CO—;
• —(CH2)pN(R1)SO2—;
• or —COO—;
• Q represents lower alkylene;
• lower alkenylene;
• M represents hydrogen;
• cycloalkyl;
• aryl;
• heterocyclyl;
• heteroaryl;
• L represents —R3;
• —COR3;
• —COOR3;
• —CONR2R3;
• —SO2R3;
• —SO2NR2R3;
• —COCH(Aryl)2;
• R1 represents hydrogen;
• lower alkyl;
• lower alkenyl;
• lower alkinyl;
• cycloalkyl;
• aryl;
• cycloalkyl-lower alkyl;
• R2 and R2′ independently represent hydrogen;
• lower alkyl;
• lower alkenyl;
• cycloalkyl;
• cycloalkyl-lower alkyl;
• R3 represents hydrogen;
• lower alkyl;
• lower alkenyl;
• cycloalkyl;
• aryl;
• heteroaryl;
• heterocyclyl;
• cycloalkyl-lower alkyl;
• aryl-lower alkyl;
• heteroaryl-lower alkyl;
• heterocyclyl-lower alkyl;
• aryloxy-lower alkyl;
• heteroaryloxy-lower alkyl, whereby these groups may be unsubstituted or mono-, di- or trisubstituted with hydroxy, —OCOR2, —COOR2, lower alkoxy, cyano, —CONR2R2′, —CO-morpholin-4-yl, —CO-((4-loweralkyl)piperazin-1-yl), —NH(NH)NH2, —NR4R4′ or lower alkyl, with the proviso that a carbon atom is attached at the most to one heteroatom in case this carbon atom is sp3-hybridized;
• R4 and R4′ independently represent hydrogen;
• lower alkyl;
• cycloalkyl;
• cycloalkyl-lower alkyl;
• hydroxy-lower alkyl;
• —COOR2;
• —CONH2;
• k is the integer 0 or 1;
• m and n represent the integer 0 or 1, with the proviso that in case m represents the integer 1, n is the integer 0;
• in case n represents the integer 1, m is the integer 0;
• in case k represents the integer 0, n represents the integer 0;
• p is the integer 1, 2, 3 or 4;
• r is the integer 1, 2, 3, 4, 5, or 6;
• s is the integer 1, 2, 3, 4, or 5;
• t is the integer 1, 2, 3, or 4;
• u is the integer 1, 2, or 3;
• and
• v is the integer 2, 3, or 4,
• or optically pure enantiomers, racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates, or the meso-form of the compound;
• or pharmaceutically acceptable salts, solvent complexes or morphological forms of the compound.