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AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsTsuyoshi Morishita, Kazuhiro Sakurada, Keiko Suzuki, Shun-ichi Ikeda
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An object of the present invention is to provide a nerve regenerating drug, an agent for the promotion of neuropoiesis of a neural stem cell, a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis, and a method of the manufacture of the neuron. In order to achieve the object, the invention provides a nerve regenerating drug comprising a substance that inhibits the activity of glycogen synthase kinase-3, as an active ingredient; an agent for the promotion of neuropoiesis of a neural stem cell comprising the substance as an active ingredient; a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis; and a method of the manufacture of the neuron. The medical drug according to the invention is useful as a therapeutic drug for neurological diseases such as Parkinson's disease, Alzheimer's disease, Down's disease, cerebrovascular disorder, cerebral stroke, spinal cord injury, Huntington's chorea, multiple sclerosis, amyotrophic lateral sclerosis, epilepsy, anxiety disorder, schizophrenia, depression and manic depressive psychosis.
A method for regenerating nerve comprising administering to a patient in need thereof, a therapeutically effective amount of a pharmaceutical composition which comprises a substance that inhibits the activity of GSK-3, as an active ingredient.
20-37. (canceled)
A method of the manufacture of a neuron which comprises culturing a neural stem cell in the presence of the substance that inhibits the activity of GSK-3 to allow neogenesis of the neuron, and collecting the neuron from the culture.
39-41. (canceled)
Dependencies are inferred from the claim text.