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US 2006/0217361 A1Published application
Bicyclic 6-alkylidene-penems as beta-lactamase inhibitors
AssigneeWyeth
InventorsAranapakam Venkatesan, Tarek Mansour, Takao Abe, Itsuki Yamamura, Tsuyoshi Takasaki, Atul Agarwal, Osvaldo Santos, Fuk-Wah Sum, Yang-I Lin
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Abstract
The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
Claims39
A compound of formula I:
- wherein:
- one of A and B is hydrogen and the other is an optionally substituted fused bicyclic heteroaryl group;
- X is O or S;
- R5 is H, C1-C6 alkyl, C5-C6 cycloalkyl, or CHR3OCOC1-C6alkyl;
- and
- R3 is hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;
- or a pharmaceutically acceptable salt thereof.
4 more elements
A method for the treatment of bacterial infection or disease in a patient in need thereof which comprises providing to said patient an effective amount of a compound of formula I:
- wherein:
- one of A and B is hydrogen and the other is an optionally substituted fused bicyclic heteroaryl group;
- X is O or S;
- R5 is H, C1-C6 alkyl, C5-C6 cycloalkyl, CHR3OCOC1-C6alkyl;
- and
- R3 is hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl;
- or a pharmaceutically acceptable salt thereof.
4 more elements
A pharmaceutical composition which comprises a pharmaceutically acceptable carrier and an effective amount of a compound of formula I:
- wherein:
- one of A and B is hydrogen and the other is an optionally substituted fused bicyclic heteroaryl group;
- X is O or S;
- R5 is H, C1-C6 alkyl, C5-C6 cycloalkyl, CHR3OCOC1-C6alkyl;
- and
- R3 is hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.