Use of derivatives of cholest-4-en-3-one as medicaments, pharmaceutical compositions containing same, novel derivatives and preparation method thereof
AssigneeTrophos
InventorsThierry Bordet, Cyrille Drouot, Bruno Buisson
Life of this patent
Estimating the term…
Abstract
Compound of formula I where X=O or ═N—OH group, R represents a group chosen from A=hydrogen or together with B a carbon-carbon bond, B=hydrogen, hydroxy or together with A a carbon-carbon bond, C, D, E, F=hydrogen or together with D a carbon-carbon bond, or the one of its addition salts with pharmaceutically acceptable acids, with the exception of a few compounds, as a medicament, use in particular as neuroprotectors, novel compounds of formula I and pharmaceutical compositions.
Claims27
A compound corresponding to the formula I
- in which X represents an oxygen atom or an ═N—OH group,
- R represents a group chosen from
- A represents a hydrogen atom or together with B a carbon-carbon bond,
- B represents a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond,
- C represents a hydrogen atom or together with D a carbon-carbon bond,
- D represents a hydrogen atom or together with C a carbon-carbon bond,
- E represents a hydrogen atom or together with F a carbon-carbon bond,
- F represents a hydrogen atom or together with E a carbon-carbon bond,
- or one of its addition salts with pharmaceutically acceptable acids, with the exception of cholest-4-en-3-one, 24-ethylcholest-4,22-dien-3-one, 5-beta-cholestan-3-one and cholest-4,6-dien-3-one as well as cholest-4,24-dien-3-one, 24-methylcholest-4,6,22-trien-3-one, and cholest-5-en-3-one oxime.
A method for providing neuroprotection in a patient in need of neuroprotection, comprising administering an effective amount of a compound of formula I
- in which X represents an oxygen atom or an ═N—OH group,
- R represents a group chosen from
- A represents a hydrogen atom or together with B a carbon-carbon bond,
- B represents a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond,
- C represents a hydrogen atom or together with D a carbon-carbon bond,
- D represents a hydrogen atom or together with C a carbon-carbon bond,
- E represents a hydrogen atom or together with F a carbon-carbon bond,
- F represents a hydrogen atom or together with E a carbon-carbon bond,
- with the exception of cholest-4-en-3-one, 24-ethylcholest-4,22-dien-3-one, 5-beta-cholestan-3-one and cholest-4,6-dien-3-one,
- or one of its addition salts with pharmaceutically acceptable acids.
(canceled)
Dependencies are inferred from the claim text.