Novel oncogene, recombinant protein derived therefrom, and uses thereof
AssigneesNEC Corporation, Masahiko Kuroda
InventorsAkira Saito, Masahiko Kuroda
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AssigneesNEC Corporation, Masahiko Kuroda
InventorsAkira Saito, Masahiko Kuroda
Estimating the term…
The present invention identifies the total nucleotide sequence of a novel oncogene from human, which is directly involved in such a cancerization mechanism as for cervical cancer induced by HPV infection of cervical epithelial cell and the amino acid sequence of an oncogenic protein encoded thereby, and to provide a full-length polynucleotide encoding a peptide chain of the oncogenic protein derived from the novel oncogene, which can be used for recombinant production of the oncogenic protein, and the peptide chain of the oncogenic protein produded recombinantly therewith. Specifically, the present invention provides a novel oncogene polynucleotide from human involving development of cervical cancer, comprising a nucleotide sequence encoding an amino acid sequence of SEQ. ID. No.1, particularly a polynucleotide of the nucleotide sequence of SEQ. ID. No.2.
A recombinant polypeptide or its salts comprising the amino acid sequence of SEQ. ID. No.1.
A recombinant oncogenic protein comprising an amino acid sequence of SEQ. ID. No.1.
A double strand of short-chain interfering RNA (siRNA) capable of inhibiting expression of a target mRNA in a cervical cancer cell, wherein the siRNA has a nucleotide sequence:
Dependencies are inferred from the claim text.