Antisense oligonucleotide modulation of STAT3 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorJames Karras
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Abstract
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
Claims14
1-18. (canceled)
A modified or unmodified antisense compound 20 to 30 nucleobases in length targeted to a nucleic acid molecule encoding human STAT3, wherein said antisense compound comprises a sequence selected from the group consisting of SEQ ID NO:
- 159, 161, 169, 184, 185, 198, 226, 230, 240, 241, 291, 293, 294, 295, 296, 297, 298, 299, 354, 355, 356, and 357, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.