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US 2006/0217338 A1Published application
Influenza nucleic acids, polypeptides, and uses thereof
AssigneeUniversity of Massachusetts
InventorsShan Lu, Shixia Wang
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Abstract
Codon-optimized nucleic acids encoding influenza polypeptides and uses of the nucleic acids and polypeptides for inducing immune responses are provided herein.
Claims43
An isolated nucleic acid molecule comprising:
- a sequence encoding an influenza type hemagglutinin (HA) polypeptide or antigenic fragment thereof, or an influenza neuraminidase (NA) polypeptide or antigenic fragment thereof, wherein the sequence has been codon-optimized for expression in a human cell.
An isolated nucleic acid molecule comprising a sequence encoding two or more copies of an extracellular portion of an influenza M2 polypeptide.
A nucleic acid composition comprising:
- (a) a first sequence encoding a first type of influenza polypeptide of a first influenza subtype;
- and
- (b) a second sequence encoding the first type of influenza polypeptide of a second influenza subtype.
A nucleic acid composition comprising:
- (a) a first sequence encoding a first influenza polypeptide of a first influenza subtype;
- and
- (b) a second sequence encoding a second influenza polypeptide of the first influenza subtype or a second influenza subtype;
- wherein the sequence of (a) and the sequence of (b) have been codon-optimized for expression in a mammalian cell.
1 more element
Dependencies are inferred from the claim text.