Synergisitic stimulation of the immune system using immunostimulatory oligonucleotides and/or immunomer compounds in conjunction with cytokines and/or chemotherapeutic agents or radiation therapy

A method for therapeutically treating a vertebrate having cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, skin disorders, allergy, asthma or a disease caused by a pathogen, such method comprising administering to the vertebrate an immunostimulatory oligonucleotide having the structure 5′-TCRTCRTTG-X-GTTRCTRCT-5′ (SEQ ID NO:

• 42);
• wherein X is a glycerol linker and R is 2′-deoxy-7-deazaguanosine.

A method for generating an immune response in a vertebrate, the method comprising administering to the vertebrate an immunostimulatory oligonucleotide having the structure 5′-TCRTCRTTG-X-GTTRCTRCT-5′ (SEQ ID NO:

• 42);
• wherein X is a glycerol linker and R is 2′-deoxy-7-deazaguanosine.

A method for preventing cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, skin disorders, allergy, asthma or a disease caused by a pathogen in a vertebrate, such method comprising administering to a vertebrate an immunostimulatory oligonucleotide having the structure 5′-TCRTCRTTG-X-GTTRCTRCT-5′ (SEQ ID NO:

• 42);
• wherein X is a glycerol linker and R is 2′-deoxy-7-deazaguanosine.