RNAi modulation of the Nogo-L or Nogo-R gene and uses thereof

An iRNA agent including a sense strand, wherein the sense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the sense strand sequences of any one agent selected from the group consisting of:

• agents number 6000 to 6029, and an antisense strand wherein the antisense strand comprises at least 15 contiguous nucleotides of the antisense sequences of any one agent selected from the group consisting of:
• agents number 6000. to 6029, and wherein the iRNA agent reduces the amount of Nogo-R mRNA present in cultured human cells after incubation with these agents by more than 40% compared to cells which have not been incubated with the agent.

An iRNA agent comprising a sense strand and an antisense strand each comprising a sequence of at least 16, 17 or 18 nucleotides which is essentially identical to one of the sequences of any one agent selected from the group consisting of:

• agents number 6000 to 6029, except that not more than 1, 2 or 3 nucleotides per strand, respectively, have been substituted by other nucleotides (e.g. adenosine replaced by uracil), while essentially retaining the ability to inhibit Nogo-R expression.

An iRNA agent including a sense strand, wherein the sense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the sense strand sequences of any one agent selected from the group consisting of:

• agents number 6030 to 6476, and an antisense strand wherein the antisense strand comprises at least 15 contiguous nucleotides of the antisense sequences of any one agent selected from the group consisting of:
• agents number 6030 to 6476 and 6837, and wherein the iRNA agent reduces the amount of Nogo-L and/or Nogo-A mRNA present in cultured human cells after incubation with these agents by more than 40% compared to cells which have not been incubated with the agent.

An iRNA agent comprising a sense strand and an antisense strand each comprising a sequence of at least 16, 17 or 18 nucleotides which is essentially identical to one of the sequences of any one agent selected from the group consisting of:

• agents number 6030 to 6476 and 6837, except that not more than 1, 2 or 3 nucleotides per strand, respectively, have been substituted by other nucleotides (e.g. adenosine replaced by uracil), while essentially retaining the ability to inhibit Nogo-L expression.

A method of treating a human subject having a pathological process mediated in part by Nogo-R comprising administering an iRNA agent, wherein the iRNA agent comprises a sense strand wherein the sense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the sense strand sequences any one of the agents, agent numbers 6000 to 6029, and an antisense strand, wherein the antisense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the antisense strand sequences of any one of the agents, agent numbers 6000 to 6029.

A method of treating a human subject having a pathological process mediated in part by Nogo-L or Nogo-A comprising administering an iRNA agent, wherein the iRNA agent comprises a sense strand wherein the sense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the sense strand sequences any one of the agents, agent numbers 6030 to 6476 and 6837, and an antisense strand, wherein the antisense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the antisense strand sequences of any one of the agents, agent numbers 6030 to 6476 and 6837.

A method of reducing the expression of a Nogo-L or Nogo-A gene in a cell comprising providing an iRNA agent to said cell, wherein the iRNA agent comprises a sense strand wherein the sense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the sense strand sequences any one of the agents, agent numbers 6030 to 6476 and 6837, and an antisense strand, wherein the antisense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the antisense strand sequences of any one of the agents, agent numbers 6030 to 6476 and 6837.

A method of reducing the expression of a Nogo-R gene in a cell comprising providing an iRNA agent to said cell, wherein the iRNA agent comprises a sense strand wherein the sense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the sense strand sequences any one of the agents, agent numbers 6000 to 6029, and an antisense strand, wherein the antisense strand comprises at least 15 contiguous nucleotides that differ by no more than 1, 2, or 3 nucleotides from the antisense strand sequences of any one of the agents, agent numbers 6000 to 6029.