Method of controlled ovarian hyperstimulation and pharmaceutical kit for use in such method

A method of treating infertility in a mammalian female, said method comprising administering to said female:

• a substance having follicle stimulating hormone activity (FSH substance) selected from the group consisting of urinary FSH (uFSH), recombinant FSH (recFSH), agonistic FSH muteins and/or heterocyclic low molecular weight compounds of less than 600 daltons displaying FSH agonistic activity in an amount effective to stimulate follicular development;
• and
• anti-P in an effective amount to prevent a premature endogenous LH-surge;
• followed by administering:
• a meiosis and luteinisation inducing substance (ML substance) having or inducing luteinising hormone activity, said ML substance being selected from the group consisting of recombinant LH, urinary chorionic gonadotropin (uCG), recombinant CG, progestogen, gonadotropin releasing hormone (GnRH), GnRH agonists and other substances capable of stimulating the release of LH by the pituitary, chimaeric or otherwise modified gonadotropins with LH-activity, low molecular weight compounds with LH activity and mixtures thereof, in an amount effective to stimulate resumption of meiosis and luteinisation;
• and
• a progestogen in an amount effective to prevent or suppress symptoms of progesterone antagonism and/or deficiency, wherein the progestogen is administered within 24 hours of the first administration of the ML substance.