5-CNAC as oral delivery agent for parathyroid hormone fragments
OwnerMoise Azria, Simon Batemaninventors
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Abstract
Pharmaceutical compositions for the effective oral delivery of a parathyroid hormone, PTH, as well as methods for administration of the compositions are provided. Additionally, methods for stimulating new bone formation and treating and/or preventing osteoporosis are also provided.
Claims21
A pharmaceutical composition for oral delivery comprising a PTH fragment and N-(5-chlorosalicviovl)-8-aminocaprylic acid and pharmaceutically acceptable salts and esters thereof, said PTH fragment selected from PTH (1-28) to PTH (1-41).
A pharmaceutical composition for oral delivery comprising a PTH fragment and a compound selected from the free acid, the disodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid and the monohydrate thereof, said PTH fragment selected from PTH (1-28) to PTH (1-41).
A pharmaceutical composition for oral delivery comprising a PTH fragment and the disodium salt of N-(5-chloro-salicyloyl)-8-aminocaprylic acid.
A method for orally administering an effective dose of PTH comprising orally administering to a patient in need of PTH a pharmaceutical composition comprising a therapeutically effective amount of a PTH fragment and 5-CNAC, said PTH fragment selected from PTH (1-28)-PTH (1-41).
A method of stimulating new bone formation comprising orally administering to a patient in need of new bone formation a pharmaceutical composition comprising a therapeutically effective amount of a PTH fragment and 5-CNAC, said PTH fragment selected from PTH (1-28)-PTH (1-41).
A method of treatment or prevention of osteoporosis comprising orally administering to a patient in need of said treatment or prevention a pharmaceutical composition comprising a therapeutically effective amount of a PTH fragment and 5-CNAC, said PTH fragment selected from PTH (1-28)-PTH (1-41).
The use of 5-CNAC for the preparation of a pharmaceutical composition suitable for the oral delivery of PTH fragments selected from PTH (1-28)-PTH (1-41).
Dependencies are inferred from the claim text.