Fibroblast growth factor 1 (FGF-1) used for skin care

Abstract

Provided are compositions comprising a fibroblast growth factor 1 (FGF-1) for skin care, and methods of use of such compositions. The FGF-1 is constructed into a recombinant expression vector, and characterized by the molecular characteristics. The FGF-1 can modulate mitogenic activities and mediate both the FGF-2 and KGF signaling pathway that can promote proliferation of fibroblast cells and epidermal cells. A mutant FGF-1 has the longer half life than wild type has in virtue of its capabilities of anti-oxidization or no further proteolytic degradation.

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