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AssigneesBiomarck Pharmaceuticals, Ltd., North Carolina State University
InventorsShuji Takashi, Indu Parikh, Kenneth Adler, Linda Martin, Yuehua Li
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The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from the vesicles or granules in the inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. MANS peptide and active fragments thereof are useful in such methods.
A method of inhibiting the exocytotic release of at least one inflammatory mediator from at least one inflammatory cell comprising contacting the at least one inflammatory cell, which cell comprises at least one inflammatory mediator contained within a vesicle inside the cell, with at least one peptide selected from the group consisting of a MANS peptide and an active fragment thereof in an effective amount to reduce the release of said inflammatory mediator from said inflammatory cell as compared to the release of said inflammatory mediator from the same type of inflammatory cell that would occur in the absence of said at least one peptide.
A method of inhibiting the release of at least one inflammatory mediator from at least one inflammatory cell in a tissue and/or fluid of a subject comprising:
Dependencies are inferred from the claim text.