Compositions with hematopoietic and immune activity
AssigneeGenentech, Inc.
InventorsNapoleone Ferrara, Jennifer Lecouter
Life of this patent
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Abstract
The present invention provides methods of using Bv8 and EG-VEGF polypeptides and nucleic acids to promote hemtopoiesis. Also provided herein are methods of screening for modulators of Bv8 and EG-VEGF activity. Furthermore, methods of treatment using Bv8 and EG-VEGF polypeptides or Bv8 and EG-VEGF antagonists are provided.
Claims52
-71. (canceled)
A method of inducing proliferation of bone marrow cells, lymphoid lineage progenitor cells, or progeny thereof, comprising contacting said cells with Bv8, EG-VEGF, or a combination thereof.
A method for treating an immunodeficiency disorder in a mammal, comprising administering to said mammal Bv8, EG-VEGF, or a combination thereof.
A method for treating an autoimmune disorder or a disorder associated with abnormal hematopoiesis in a mammal, comprising administering to said mammal a Bv8 antagonist, EG-VEGF antagonist, or combination thereof.
An article of manufacture comprising:
- a container;
- a Bv8 antagonist, EG-VEGF antagonist, or combination thereof;
- and
- instructions for using the Bv8 antagonist, EG-VEGF antagonist, or combination thereof to treat hematological disorders.
An article of manufacture, comprising:
- a container,
- Bv8, EG-VEGF, or a combination thereof, and
- instructions for using the Bv8, EG-VEGF, or combination thereof to treat an immunological disorder or a condition associated with abnormal hematopoiesis.
Dependencies are inferred from the claim text.