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AssigneeAmbrx, Inc.
InventorsZhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
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Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
A method for treating a disorder, condition or disease, the method comprising administering a therapeutically effective amount of a non-natural amino acid polypeptide comprising at least one oxime-containing non-natural amino acid, wherein the oxime-containing non-natural amino acid is incorporated at a specific site within the polypeptide using a translation system comprising:
A method for detecting the presence of a polypeptide in a patient, the method comprising administering an effective amount of a homologous non-natural amino acid polypeptide comprising at least one oxime-containing non-natural amino acid, wherein the oxime-containing amino acid is incorporated at a specific site within the polypeptide using a translation system comprising:
A method for easing the isolation properties of a polypeptide comprising utilizing a homologous non-natural amino acid polypeptide comprising at least one oxime-containing non-natural amino acid, wherein the oxime-containing amino acid is incorporated at a specific site within the polypeptide using a translation system comprising:
Dependencies are inferred from the claim text.