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US 2006/0216835 A1Published application
Method of separating unattached Raman-active tag from bioassay or other reaction mixture
AssigneeGeneral Electric Company
InventorFrank Mondello
Life of this patent
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Abstract
A superparamagnetic Raman-active complex that includes a Raman-active tag, a target, and a superparamagnetic particle is disclosed. A method of applying a magnetic field to a mixture is also disclosed. The mixture includes a Raman-active tag unattached to a target and a superparamagnetic Raman-active complex. Also disclosed is a method of separating a Raman-active tag unattached to a target from a Raman-active complex. The Raman-active complex includes a Raman-active tag attached to a target.
Claims23
A method comprising:
- applying a magnetic field to a mixture comprising at least one Raman-active active tag unattached to a target and at least one superparamagnetic Raman-active complex that comprises a target.
A method comprising:
- applying a magnetic field to a mixture comprising at least one Raman-active tag unattached to a target and at least one superparamagnetic Raman-active complex, wherein the Raman-active tag comprises a Raman-active particle and a target-binding moiety comprising an antibody.
A superparamagnetic Raman-active complex comprising:
- a Raman-active tag attached to a target;
- and
- a superparamagnetic particle attached to the target or the Raman-active tag.
Dependencies are inferred from the claim text.