Assay devices that utilize hollow particles
AssigneeKimberly-Clark Worldwide, Inc.
InventorsKaiyuan Yang, Ning Wei, Rosann Kaylor, Chibueze Chidebelu-Eze, Zdravko Atanassov
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Abstract
Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
Claims7
An assay device for detecting an analyte in a test sample, the assay device comprising:
- a porous membrane that defines a detection zone, wherein a biological receptive material is immobilized within the detection zone;
- and
- detection probes that contain latex particles having an average size of from about 0.1 nanometer to about 100 microns, wherein the latex particles individually define a hollow interior constituting at least about 20% of the spatial volume occupied by the particle, the latex particles further being conjugated with a specific binding member for the analyte;
- wherein the detection probes are capable of generating a detection signal when present within the detection zone.
Dependencies are inferred from the claim text.