cGMP-binding, cGMP-specific phosphodiesterase materials and methods
AssigneesICOS Corporation, University of Washington
InventorsJoseph Beavo, Jackie Corbin, Kenneth Ferguson, Sharron Francis, Ann Kadlecek, Kate Loughney, Linda McAllister-Lucas, William Sonnenburg, Melissa Thomas
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Abstract
The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
Claims18
A purified and isolated polynucleotide encoding cGB-PDE.
A polypeptide or peptide capable of specifically binding to cGB-PDE.
An antisense polynucleotide specific for a polynucleotide encoding cGB-PDE.
A DNA sequence encoding cGB-PDE and selected from the group consisting of:
- (a) the DNA sequence set out in SEQ ID NO:
- 9 or 22;
- (b) a DNA which hybridizes under stringent conditions to the DNA of (a);
- and
- (c) a DNA sequence which, but for the redundancy of the genetic code, would hybridize under stringent conditions to a DNA sequence of (a) or (b).
Dependencies are inferred from the claim text.