Hyaluronan synthase gene and uses thereof
AssigneeThe Board of Regents of the University of Oklahoma
InventorsPaul Weigel, Kshama Kumari, Paul DeAngelis
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Abstract
The present invention relates to a recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA. The recombinantly produced, enzymatically active hyaluronan synthase may be produced from a hyaluronan synthase gene isolated from a microbial source, such as a streptococcal source.
Claims11
A recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual- action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA.
An isolated, recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA.
A purified, recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual- action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA.
A recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual- action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA, and wherein the recombinantly produced, enzymatically active hyaluronan synthase is produced from a hyaluronan synthase gene isolated from a microbial source.
A recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual- action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA, and wherein the recombinantly produced, enzymatically active hyaluronan synthase is produced from a hyaluronan synthase gene isolated from a streptococcal source.
Dependencies are inferred from the claim text.