Membrane for removing proteases from liquids
AssigneeSartorius AG
InventorsWolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Horl
Life of this patent
Estimating the term…
Abstract
The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
Claims15
A membrane for removing proteases from a fluid, comprising a functionalized microporous membrane body containing functional groups capable of chemically coupling with protease inhibitors and at least one protease inhibitor capable of selectively binding proteases, wherein said at least one protease inhibitor is coupled to said membrane body via said functional groups.
The membrane of any of claims 1-10 wherein said microporous membrane body contains two different protease inhibitors.
A device for removing proteases from biological fluids and pharmaceutical solutions comprising a housing having a fluid inlet and a fluid outlet, said housing containing four membrane bodies arranged therein in series, wherein said membrane bodies each comprise a functionalized microporous membrane body containing functional groups capable of chemically coupling with protease inhibitors and at least one protease inhibitor capable of selectively binding with proteases, wherein said at least one protease inhibitor is coupled to said membrane body via said functional groups.
Dependencies are inferred from the claim text.