CASH (CASPASE HOMOLOGUE) with death effector domain, modulators of the function of FAS
AssigneeYeda Research and Development Co. Ltd.
InventorsDavid Wallach, Yura Goltsev, Andrei Kovalenko, Eugene Vappolomeev, Vadim Brodianski
Life of this patent
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Abstract
Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use.
Claims23
A molecule comprising a DNA sequence encoding a polypeptide which is capable of binding to one or more of MORT-1, MACH and MORT-1 binding protein Mch4, which polypeptide has the amino acid sequence of:
- (a) a G1 protein isoform whose sequence is that of SEQ ID NO:4;
- (b) a fragment of (a) which is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4;
- (c) an analog of (a) which differs from the sequence of (a) by no more than ten changes in the amino acid sequence of (a), each said change being a substitution, deletion and/or insertion of a single amino acid, which analog is capable of binding to one or more of MORT-1, MACH and MORT-1 binding protein Mch4;
- or
- (d) a derivative of (a), (b) or (c) by modification of a functional group which occurs as a side chain or an N- or C-terminal group of one or more amino acid residues thereof without changing one amino acid to another of the twenty commonly occurring natural amino acids, which derivative is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4.
A polypeptide which is capable of binding to one or more of MORT-1, MACH and MORT-1 binding protein Mch4, which polypeptide has the amino acid sequence of:
- (a) a G1 protein isoform whose sequence is that of SEQ ID NO:
- 4;
- (b) a fragment of (a) which is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4;
- (c) an analog of (a) which differs from the sequence of (a) by no more than ten changes in the amino acid sequence of (a), each said change being a substitution, deletion and/or insertion of a single amino acid, which analog is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4;
- or
- (d) a derivative of (a), (b) or (c) by modification of a functional group which occurs as a side chain or an N- or C-terminal group of one or more amino acid residues thereof without changing one amino acid to another of the twenty commonly occurring natural amino acids, which derivative is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4.
A molecule comprising a DNA sequence encoding a polypeptide which is capable of binding to one or more of MORT-1, MACH and MORT-1 binding protein Mch4, which polypeptide has the amino acid sequence of:
- (a) a protein comprising the amino acid sequence of residues 1 to 142 of SEQ ID NO:4;
- (b) a fragment of (a) which is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4;
- (c) an analog of (a) which differs from the sequence of (a) by no more than ten changes in the amino acid sequence of (a), each said change being a substitution, deletion and/or insertion of a single amino acid, which analog is capable of binding to one or more of MORT-1, MACH and MORT-1 binding protein Mch4;
- or
- (d) a derivative of (a), (b) or (c) by modification of a functional group which occurs as a side chain or an N- or C-terminal group of one or more amino acid residues thereof without changing one amino acid to another of the twenty commonly occurring natural amino acids, which derivative is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4.
A polypeptide which is capable of binding to one or more of MORT-1, MACH and MORT-1 binding protein Mch4, which polypeptide has the amino acid sequence of:
- (a) a protein comprising the amino acid sequence of residues 1 to 142 of SEQ ID NO:4;
- (b) a fragment of (a) which is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4;
- (c) an analog of (a) which differs from the sequence of (a) by no more than ten changes in the amino acid sequence of (a), each said change being a substitution, deletion and/or insertion of a single amino acid, which analog is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4;
- or
- (d) a derivative of (a), (b) or (c) by modification of a functional group which occurs as a side chain or an N- or C-terminal group of one or more amino acid residues thereof without changing one amino acid to another of the twenty commonly occurring natural amino acids, which derivative is capable of binding to one or more of MORT-1, MACH, and MORT-1 binding protein Mch4.
Dependencies are inferred from the claim text.