Peptides and methods for deactivation of organophosphorus-based nerve agents and insecticides
AssigneeThe Trustees of Columbia University in the City of New York
InventorsDonald Landry, Shi-Xian Deng
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Abstract
This invention provides methods and peptides for the inactivation of organophosphorus-based insecticides and chemical warfare agents. The instant methods include peptide screening methods, peptides and peptide libraries, related compositions of matter, articles of manufacture, and methods for prophylaxis, treatment, decontamination and detection.
Claims38
A method for determining whether a peptide forms a phosphorus-based ester with an organophosphorus agent comprising the steps of:
- (a) contacting the peptide with the agent under conditions permitting formation of a phosphorus-based ester;
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- (b) determining whether a phosphorus-based ester has formed between the peptide and the agent.
wherein the phosphorus-based ester is a phosphonate ester.
A peptide which forms a phosphorus-based ester with an organophosphorus agent, which peptide comprises a nucleophilic functional group.
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A peptide library, wherein each peptide therein comprises a nucleophilic functional group.
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Dependencies are inferred from the claim text.