Method
AssigneeAstraZeneca AB
InventorsTanjore Balganesh, Santanu Datta, Indira Ghosh
Life of this patent
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Abstract
A method for attenuating a microorganism which comprises inhibiting in the microorganism a metabolic pathway essential for viability, by promoting use of the substrate of the pathway in a different metabolic pathway which is non-essential to the microorganism whereby the substrate is unavailable to the essential pathway and the micro organism is attenuated.
Claims12
A method for attenuating a microorganism which comprises inhibiting in the microorganism a metabolic pathway essential for viability, by promoting use of the substrate of the pathway in a different metabolic pathway which is non-essential to the microorganism whereby the substrate is unavailable to the essential pathway and the micro organism is attenuated.
A method as claimed in claim 2 and wherein the presence or absence of a nutrient determines whether a metabolic pathway is essential or non-essential to the microorganism.
A method as claimed in claim 4 and wherein the enzyme to be inhibited is a kinase.
A method for identifying compounds that attenuate Mycobacterium tuberculosis which method comprises testing compounds in a test system for their ability to bind to pknG and prevent autophosphorylation.
A method for identifying compounds that attenuate Mycobacterium tuberculosis which method comprises testing compounds in a test system for their ability to bind to pknG and prevent phosphorylation of icd1 or a peptide derived from icd1.
A method for identifying compounds that attenuate Mycobacterium tuberculosis which method comprises testing compounds in a test system for their ability to bind to icd1 or a peptide derived from icd1 and prevent phosphorylation of icd1 by pknG.
A method for identifying compounds that attenuate Mycobacterium tuberculosis which method comprises testing compounds in a test system for their ability to prevent the phosphorylation and or inactivation of icd1.
Dependencies are inferred from the claim text.