Interfacial biomaterials for binding metal substrates
OwnerMark Grinstaff, Daniel Kenan +2inventors
InventorsMark Grinstaff, Daniel Kenan, Elisabeth Walsh, Crystan Middleton
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Abstract
An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.
Claims25
1-248. (canceled)
An interfacial biomaterial for binding a target metal substrate to a target biological substrate, wherein said interfacial biomaterial comprises:
- a) a first binding domain which comprises a peptide having at least 3 consecutive amino acids to about 50 consecutive amino acids, wherein the first binding domain has a binding affinity for the target metal substrate of at least 1×104 M−1;
- and
- b) a second binding domain different from the first binding domain of wherein said second binding domain comprises a peptide having at least 3 consecutive amino acids to about 50 consecutive amino acids, and wherein the second binding domain has a binding affinity for the target biological substrate of at least 1×104 M−1.
(canceled)
(canceled)
Dependencies are inferred from the claim text.