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OwnerMagnus Doeberitz, Rudiger Ridder +2inventors
InventorsMagnus Doeberitz, Rudiger Ridder, Matthias Herkert, Anja Reichert
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The present invention relates to a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of a cell cycle regulatory protein in a solubilized body sample. The present invention is particularly directed to a method for detecting cervical carcinomas, cervical intraepithelial neoplasias, or cervical carcinomas in-situ from a solubilized cervical body sample of a human subject, by solubilizing the cervical body sample in a lysis buffer, and determining the overexpression of cyclin dependent kinase inhibitor p16 in the solubilized cervical sample. The invention also concerns a test kit usable for this purpose as well as an in-vitro diagnostic device.
An in-vitro diagnostic device comprising antibodies directed against cyclin dependent kinase inhibitor p16 fixed on solid carriers, for detecting p16 in a solubilized sample.
A test kit for determining the level of cyclin dependent kinase inhibitor p16 comprising antibodies directed against cyclin dependent kinase inhibitor p16 and a lysis buffer for solubilization of a body sample.
A test kit comprising antibodies directed against cyclin dependent kinase inhibitor p16 fixed on solid carriers, for detecting p16 in a solubilized sample.
Dependencies are inferred from the claim text.