Methods for predicting and/or diagnosing the risk of gastric cancer
OwnerRobert Clancy, Gerald Panginventors
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Abstract
The present invention relates to methods of predicting the risk of developing cancer and in particular to a method for diagnosing, and/or predicting the risk of developing gastric cancer in a subject infected with Helicobacter.
Claims36
A method of diagnosing or determining the risk of developing gastric cancer in a subject with a Helicobacter infection, including:
- a) determination of IgG2 anti-H. pylori antibody level in the subject;
- and
- b) comparison of the IgG2 anti-H. pylori antibody level with a predetermined control IgG2 anti-H. pylori antibody level, wherein a reduction in the level of IgG2 anti-H. pylori antibody in the subject compared to the control indicates the presence of gastric cancer or an increased risk of developing gastric cancer.
2-22. (canceled)
A method of diagnosing or determining the risk of developing gastric cancer in a subject with a Helicobacter infection, including:
- a) determination of γIFN level in the subject;
- b) comparison of the γIFN level with a predetermined control γIFN level, wherein a reduction in the level of γIFN in the subject compared to the control indicates the presence of gastric cancer or an increased risk of developing gastric cancer.
A method of diagnosing or determining the risk of developing gastric cancer in a subject with a Helicobacter infection, including:
- a) determination of IL-4 level in the subject;
- b) comparison of the IL-4 level with a predetermined control IL-4 level, wherein an elevation in the level of IL-4 in the subject compared to the control indicates the presence of gastric cancer or an increased risk of developing gastric cancer.
A method of predicting the risk of, or diagnosing, gastric cancer in a subject having a Helicobacter infection by
- a) determining the frequency of IgG2 anti-H. pylori antibody- and/or γIFN- and/or IL-4-producing cells in the subject's blood;
- and
- b) comparison of the frequency of IgG2 anti-H. pylori antibody- and/or γIFN- and/or IL-4-producing cells in the subject's blood with a predetermined control level, wherein a reduction in the level of IgG2 anti-H. pylori antibody- and/or γIFN-producing cells and/or an elevation in IL-4-producing cells in the subject's blood indicates the presence of gastric cancer or an increased risk of developing gastric cancer.
A method of predicting the risk of, or diagnosing, gastric cancer in a subject having a Helicobacter infection by
- a) determining the frequency of IgG2 anti-H. pylori antibody and/or γIFN and/or IL-4-producing cells in the subject's gastric mucosa;
- and
- b) comparison of the frequency of IgG2 anti-H. pylori antibody and/or γIFN and/or IL-4-producing cells in the subject's gastric mucosa with a predetermined control level, wherein a reduction in the level of IgG2 anti-H. pylori antibody- and/or γIFN-producing cells and/or an elevation in IL-4-producing cells in the subject's gastric mucosa indicates the presence of gastric cancer or an increased risk of developing gastric cancer.
Dependencies are inferred from the claim text.