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US 2006/0216753 A1Published application
Binding Proteins as Biosensors
AssigneeBecton, Dickinson and Company
InventorsJ. Pitner, Jason Gestwicki, Zachary Pfieffer, Helen Hsieh
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Abstract
The invention is directed to compositions of mutated binding proteins containing thiol groups for coupling to sensor surfaces, analyte biosensor devices derived there from, and methods of their use as analyte biosensors both in vitro and in vivo.
Claims13
A biosensor comprising:
- a. at least one mutated glucose/galactose binding protein having at least one substituted or added cysteine group;
- and
- b. at least one sensor surface wherein said mutated binding protein is coupled through said cysteine group to said at least one surface;
- wherein said at least one sensor surface comprises a metal layer having conduction band electrons capable of resonating with light, thereby providing a detectable signal.
1 more element
The biosensor of 8 wherein said mutated glucose/galactose binding protein further includes a histidine tag.
Dependencies are inferred from the claim text.