Genes differentially expressed in breast cancer
AssigneeChiron Corporation
InventorsJoerg Kaufmann, Greg Harrowe, Christoph Reinhard, Sanmao Kang
Life of this patent
Estimating the term…
Abstract
A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.
Claims16
1-11. (canceled)
An isolated polypeptide comprising amino acids at least 95% identical to amino acids selected from the group consisting of:
- (a) amino acids about 1 to about 273 of SEQ ID NO:2;
- (b) amino acids about 2 to about 273 of SEQ ID NO:2;
- and
- (c) amino acids 26 to 273 of SEQ ID NO:2.
An isolated polypeptide wherein, except for at least one conservative amino acid substitution, said polypeptide has an amino acid sequence selected from the group consisting of:
- (a) amino acids about 1 to about 273 of SEQ ID NO:2;
- (b) amino acids about 2 to about 273 of SEQ ID NO:2;
- and
- (c) amino acids 26 to 273 of SEQ ID NO:2.
An isolated polypeptide comprising amino acids selected from the group consisting of:
- (a) amino acids about 1 to about 273 of SEQ ID NO:2;
- (b) amino acids about 2 to about 273 of SEQ ID NO:2;
- and
- (c) amino acids 26 to 273 of SEQ ID NO:2.
An epitope-bearing portion of the polypeptide of SEQ ID NO:2.
18-21. (canceled)
A non-naturally occurring fusion protein comprising a first protein segment and a second protein segment fused to each other by means of a peptide bond, wherein the first protein segment comprises at least six contiguous amino acids selected from an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO:1 or the complement thereof.
29-37. (canceled)
Dependencies are inferred from the claim text.