Methods and reagents for diagnosing and treating gliomas
AssigneeBar-Ilan University
InventorChaya Brodie
Life of this patent
Estimating the term…
Abstract
Methods and reagents for diagnosing and treating gliomas. The disclosed methods and reagents rely upon measurement or regulation of RTVP-1 in cells of the central nervous system. Also disclosed is an RTVP gene promoter, cells transformed with such vectors and transgenic animals with at least one exogenous copy of the promoter in their genomes are further disclosed.
Claims39
A method of diagnosing glioma in a subject, the method comprising conducting a quantitative analysis of an RTVP expression level in a biological sample taken from the subject.
A diagnostic kit for analysis of a biological sample removed from a subject, the kit comprising:
- (a) reagents suitable for conducting a quantitative analysis of an RTVP expression level in the biological sample.
A method of influencing a clinical progression of glioma in a subject, the method comprising reducing a biological activity of RTVP-1 in the subject.
A pharmaceutical composition for treating glioma, the pharmaceutical composition comprising as an active ingredient a physiologically effective amount of an agent which reduces a biological activity of RTVP-1 in a subject treated with the pharmaceutical composition and a physiologically acceptable carrier and excipient.
A method of formulation of a pharmaceutical composition for treatment of glioma, the method comprising combining an agent which reduces a biological activity of RTVP-1 with a physiologically acceptable carrier and excipient.
An isolated nucleic acid sequence characterized by an ability to positively regulate a downstream gene, the sequence comprising an item selected from the group consisting of SEQ. ID. NO.:
- 25 and a functional portion thereof.
Dependencies are inferred from the claim text.