Method and system for estimating gene expression data
OwnerAntonio Possolo, Jay Silkworth +1inventors
InventorsAntonio Possolo, Jay Silkworth, Kati Illouz
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Abstract
A method and system are provided for measuring differential gene expression that is induced on multiple experimental subjects by controlled, multiple experimental factors, measured using microarrays or other devices that measure the activity of multiple probes per gene. The information in the readings made from all the probes in the microarrays or other devices that received the experimental samples is extracted simultaneously, without prior summarization or aggregation at the gene level, by employing a multi-factor model that explicitly accounts for differences in expression between genes, between probes from the same gene, and between the effects of the experimental factors.
Claims20
A method for assessing gene expression, the method comprising:
- analyzing a set of gene expression data for a plurality of genes acquired by a plurality of probes for each gene and for a plurality of subjects, wherein the gene expression data for all the probes from the same gene is analyzed simultaneously.
A computer readable media, comprising:
- code adapted to analyze a set of gene expression data for a plurality of genes acquired by a plurality of probes for each gene and for a plurality of subjects, wherein the gene expression data for all the probes from the same gene is analyzed simultaneously.
A system for assessing gene expression, the system comprising
- an interface for receiving gene expression data acquired from a plurality of subjects and acquired for a plurality of genes per subject using a plurality of probes per gene;
- and
- a processor configured to simultaneously analyze the gene expression data.
Dependencies are inferred from the claim text.