Back to results
US 2006/0216710 A1Published application
Novel centrosome-associated protein and applications thereof
AssigneeCentre National Be La Recherche
InventorsDominique Giorgi, Sylvie Rouquier, Jean-Michel Saffin
Life of this patent
Estimating the term…
Abstract
The invention relates to a novel centrosome-associated protein, to the polynucleotide coding for the aforementioned protein and to the applications of said protein and polynucleotide. The overexpression of the inventive protein disrupts the mitotic spindle assembly and leads to aberrant and abortive mitoses.
Claims32
1-27. (canceled)
A medicinal product, which comprises an active component selected from the group consisting of:
- a) a protein, ASAP, selected from the group consisting of a human protein of sequence SEQ ID NO:
- 1 and the proteins for which the sequence exhibits at least 80% identity or at least 90% similarity, with the entire sequence SEQ ID NO:
- 1,
- b) a peptide of at least 10 consecutive amino acids of the protein defined in a),
- c) a monoclonal or polyclonal antibody capable of specifically recognizing the protein defined in a) or the peptide defined in b),
- d) a polynucleotide encoding the protein defined in a) or the peptide defined in b), or a polynucleotide that is antisense to the preceding polynucleotide,
- e) a polynucleotide fragment of at least 15 consecutive nucleotides of the polynucleotide defined in d) or a fragment that is antisense to the preceding fragment,
- f) an expression vector comprising the polynucleotide defined in d) or the fragment defined in e), and
- g) a host cell transformed with the polynucleotide defined in d), the fragment defined in e) or the vector defined in f).
6 more elements
An isolated protein, ASAP, which is a human protein of sequence SEQ ID NO:
- 1 or a murine protein of sequence SEQ ID NO:
- 46.
Dependencies are inferred from the claim text.