Method of separating unattached Raman-active tag from bioassay or other reaction mixture
AssigneeGeneral Electric Company
InventorsFrank Mondello, Michael Burrell
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Abstract
A super-paramagnetic Raman-active complex that includes a Raman-active tag attached to a target and a super-paramagnetic bead attached to the target is disclosed. A method of separating a Raman or surface enhanced Raman-active tag unattached to a target from a Raman-active complex is also disclosed. The Raman-active complex includes a Raman-active tag attached to a target. The method includes providing a mixture that includes at least one Raman-active tag unattached to a target and at least one super-paramagnetic Raman-active complex; and applying a magnetic field to the mixture.
Claims27
A method of separating a Raman-active tag unattached to a target from a Raman-active complex, wherein the Raman-active complex comprises a Raman-active tag attached to a target,
- the method comprising:
- i) providing a mixture comprising at least one Raman-active tag unattached to a target and at least one super-paramagnetic Raman-active complex;
- and
- ii) applying a magnetic field to the mixture.
A method of separating a surface enhanced Raman-active tag unattached to a target from a Raman-active complex, wherein the Raman-active complex comprises a Raman-active tag attached to a target,
- the method comprising:
- i) providing a mixture comprising at least one Raman-active tag unattached to a target and at least one super-paramagnetic Raman-active complex;
- wherein the Raman-active tag comprises a Raman-active particle and a target-binding moiety comprising an antibody;
- and
- ii) applying a magnetic field to the mixture.
A super-paramagnetic Raman-active complex comprising:
- (i) a Raman-active tag attached to a target;
- and
- (ii) a super-paramagnetic bead attached to the target.
Dependencies are inferred from the claim text.