US 2006/0216494 A1 · Organic-inorganic nanocomposite coatings for implant materials and methods of preparation thereof

Abstract

The present invention provides inorganic-organic nanocomposite coatings for implant materials and methods for the production thereof. The coatings consist of a sequentially adsorbed polyelectrolyte film (SAPF) intergrown with calcium phosphate crystals. The substrate is selected from glass, polymer, metal or metal alloys. The SAPFs consist of successions of positively and negatively charged monolayers, comprising biocompatible polyelectrolytes, preferably polyaminoacids. The calcium phosphate crystals may comprise octacalcium phosphate, calcium deficient apatites, carbonate apatites, hydroxyapatite, or mixtures thereof, with particle sizes 50 nm to 2 μm. The inorganic phase is grown “in situ” within the polyelectrolyte organic matrix.

Claims20

Dependent claims

1-15. (canceled)

A method of preparing an organic-inorganic composite comprising a plurality of organic polyelectrolyte films, interspersed with inorganic bioactive particles growing through said organic films, comprising the steps of:

a. adsorbing polyelectrolytes on top of a surface so that at least one polyelectrolyte film is obtained;
b. washing the obtained film in the manner that residual polyelectrolytes are removed;
c. depositing nanosized to micron-sized particles comprising calcium phosphate on top of said polyelectrolyte films, so that at least one layer comprising bioactive inorganic material is formed;
d. washing the obtained layer in the manner that residual calcium containing solution is removed;
and
e. immersing the material into a calcifying solution in the manner that the growth of crystalline calcium phosphate through said organic polyelectrolyte films is induced and sustained.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/535,939Filed 18 Nov 2003

Priority

25 Nov 2002

Published

28 Sep 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification27 codes

A61L 24/0084
With a macromolecular matrix: containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
A61L 27/32
Inorganic materials: phosphorus-containing materials, e.g. apatite
A61L 27/34
Materials for coating prostheses: macromolecular materials
A61L 27/46
Having a macromolecular matrix: with phosphorus-containing inorganic fillers

Organic-inorganic nanocomposite coatings for implant materials and methods of preparation thereof

Life of this patent

Organic-inorganic nanocomposite coatings for implant materials and methods of preparation thereof

Life of this patent

Abstract

Claims20