Nanoparticulate corticosteroid and antihistamine formulations
AssigneeElan Pharma International Limited
InventorsGary Liversidge, Scott Jenkins, H. Bosch, Christian Wertz
Life of this patent
Estimating the term…
Abstract
Compositions comprising a nanoparticulate corticosteroid and an antihistamine are described. The compositions are useful in the prophylaxis and chronic treatment of asthma in adults and pediatric patients and for the relief of allergic conjunctivitis, symptoms of seasonal allergic rhinitis in adults and pediatric patients. Combining an antihistamine with a nanoparticulate corticosteroid in a single formulation results in improved efficacy.
Claims29
A composition comprising:
- (a) at least one antihistamine;
- (b) at least one corticosteroid having an effective average particle size of less than about 2000 nm;
- and
- (c) at least one corticosteroid.
A method of making an antihistamine and nanoparticulate corticosteroid composition comprising:
- (a) contacting particles of at least one corticosteroid with at least one surface stabilizer for a time and under conditions sufficient to provide a nanoparticulate corticosteroid composition having an effective average particle size of less than about 2,000 nm;
- and
- (b) adding at least one antihistamine to the composition,
- wherein following addition of the antihistamine the corticosteroid retains an effective average particle size of less than about 2000 nm.
A method of administering to a patient in need an antihistamine/nanoparticulate corticosteroid composition, comprising administering to the patient a composition comprising:
- (a) at least one antihistamine;
- (b) at least one nanoparticulate corticosteroid having an effective average particle size of less than about 2000 nm;
- and
- (c) at least one surface stabilizer.
Dependencies are inferred from the claim text.