Pharmaceutical compositions comprising an oligonucleotide as an active agent
OwnerSteffen Panzner, Una Rauchhaus +2inventors
InventorsSteffen Panzner, Una Rauchhaus, Gerold Endert, Stefan Fankhaenel
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Abstract
A pharmaceutical composition is disclosed, which composition comprises an oligonucleotide as an active agent, the oligonucleotide being adapted to target nucleic acids encoding CD40 thereby to modulate the expression of CD40 in mammalian cells, and a liposome as an excipient. Said liposome is an amphoteric liposome. Also disclosed is a method for the treatment or prophylaxis of a disease or condition associated with the expression of CD40 in a human or non-human animal patient by administering to said patient a therapeutically or prophylactically effective amount of such a composition.
Claims44
A pharmaceutical composition comprising an oligonucleotide as an active agent, said oligonucleotide adapted to target nucleic acids encoding CD40 so as to modulate the expression of CD40 in mammalian cells, and an amphoteric liposome as an excipient.
The pharmaceutical composition according to 14, wherein said lipid phase comprises a neutral phosphatidylcholine.
Dependencies are inferred from the claim text.