Compositions for treating drug resistance
OwnerPaul Tardi, Troy Harasym +2inventors
InventorsPaul Tardi, Troy Harasym, Murray Webb, Clifford Shew
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Abstract
Delivery vehicle compositions having stably associated therewith at least one therapeutic agent and at least one drug resistance modulator are useful in achieving a biologic effect to a drug resistance target.
Claims41
A composition which comprises delivery vehicles, said delivery vehicles having a mean diameter in the range of 50-300 nm and having stably associated therewith at least one therapeutic agent and at least one drug resistance modulator, or at least two drug resistance modulators, wherein the therapeutic agent and the drug resistance modulator or the two drug resistance modulators in combination exhibit a biologic effect to a drug resistant target.
A composition which comprises delivery vehicles, said delivery vehicles having stably associated therewith two or more drug resistance modulators.
A method to impart drug sensitivity to a subject which method comprises administering to a subject in need of such drug sensitivity a composition comprising a first drug resistance modulators stably associated with a first delivery vehicle and a composition comprising a second resistance modulator stably associated with a second delivery vehicle wherein said first and second drug resistance modulators are administered at a ratio that is non-antagonistic and wherein the pharmacokinetics of the drug delivery vehicles in the first and second compositions are coordinated.
A method to administer a treatment to a subject in need of such treatment which method comprises administering to said subject a composition comprising a therapeutic agent stably associated with a first delivery vehicle and a drug resistance modulator stably associated with a second delivery vehicle at a ratio wherein said therapeutic agent and drug resistance modulator are non-antagonistic and wherein the pharmacokinetics of the first and second delivery vehicles are coordinated.
Dependencies are inferred from the claim text.