Topical composition comprising a cyclofructan, a carrier and a drug

A composition comprising a cyclofructan (CFR), a polymeric carrier and a pharmaceutically effective drug.

The composition of claim 1, wherein said CFR is a compound of formula I,

• wherein n is from 5-11,
• R is independently from each other H, alkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, alkoxyalkylen-carbonyl, alkylcarbonyl, alkylcarbamoyl, R′3Si, or R is a saccharide minus the hydrogen atom from a hydroxy group,
• wherein R′ denotes independently of each other alkyl and phenyl.

The composition of claim 1, which is a drug delivery system.

A method of improving drug permeability in mucus tissue, which method comprises the topical administration of an effective amount of a drug in appropriate admixture with a CFR to the mucus tissue of a patient in need of such improved treatment.

A method of improving drug permeability in ocular tissue, which method comprises the topical administration of an effective amount of a drug in appropriate admixture with a CFR to the ocular tissue of a patient in need of such improved treatment.