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US 2006/0216327 A1Published application
Multilayer coating for releasing biologically-active agents and method of making
AssigneeBacterin, Inc.
InventorsTodd Madsen, Jamal Yanaki
Life of this patent
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Abstract
A composition for use with healthcare products such as medical device includes one or more biologically-active agents for release into bodily fluids. The composition can be applied to a substrate to form an erodible layer and a polymer layer. Biologically-active agent(s) are releasable from the erodible layer and the polymer layer when exposed to aqueous fluids.
Claims30
An article capable of affecting a biological process, the article comprising:
- a substrate having a surface;
- an erodible layer positioned over the surface of the substrate and comprising a release material and a first biologically-active agent releasable from the erodible layer when exposed to an aqueous fluid;
- and
- a polymer layer comprising a polymer and a second biologically-active agent releasable from the polymer layer when exposed to the aqueous fluid.
1 more element
A composition for affecting a biological process, the composition comprising:
- a release material that disintegrates in an aqueous fluid;
- a first biologically-active agent incorporated within the release material and releasable through disintegration of the release material;
- a polymer matrix;
- and
- a second-biologically active agent incorporated within the polymer matrix and releasable from the polymer matrix upon exposure to an aqueous fluid.
2 more elements
A method for coating a substrate, the method comprising:
- providing functional groups on a surface of the substrate;
- depositing a base layer on the functionalized surface, the base layer comprising:
- a release material;
- and
- a first biologically-active agent;
- and
- forming a polymer layer over the base layer, the polymer layer including a second biologically-active agent that is releasable from the polymer layer when exposed to an aqueous fluid.
4 more elements
Dependencies are inferred from the claim text.