Implantable devices formed of non-fouling methacrylate or acrylate polymers
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorStephen Pacetti
Life of this patent
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Abstract
Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Claims18
An implantable device having a coating comprising a polymer that comprises repeating units of Formula I:
- wherein R1, R2, R3, R4 and R5 are independently H, C1-C4 alkyl groups, silyl groups, siloxy groups, and phenyl,
- wherein Z is O or NH, and
- wherein X is absence, O, S, or NR6 where R6 is H, C1-C4 alkyl, or phenyl.
The implantable device of claim 9, wherein the bioactive agent is selected from the group consisting of paclitaxel, docetaxel, estradiol, nitric oxide donors, super oxide dismutases, super oxide dismutases mimics, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), tacrolimus, dexamethasone, rapamycin, rapamycin derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, ABT-578, clobetasol, prodrugs thereof, co-drugs thereof, and a combination thereof.
An absorbable device formed of a material comprising a polymer that comprises repeating units of Formula I:
- wherein R1, R2, R3, R4 and R5 are independently H, C1-C4 alkyl groups, silyl groups, siloxy groups, and phenyl,
- wherein Z is O or NH, and
- wherein X is absence, O, S, or NR6 where R6 is H, C1-C4 alkyl, or phenyl.
Dependencies are inferred from the claim text.