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OwnerBrent Atkinson, Pedro Bittman +4inventors
InventorsBrent Atkinson, Pedro Bittman, James Benedict, John Ranieri, Marsha Whitney, Donald Chickering
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The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)-lactic acid/glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device comprising any biodegradable matrix in which the nanospheres loaded with the factor combination is contained.
1-23. (canceled)
A composition comprising:
The composition of claim 1, wherein the first rate is greater than 10% per day.
The composition of claim 1, wherein the second rate is less than 1% per day.
The composition of claim 1, wherein the delivery system has a third release rate.
The composition of claim 4, wherein the third release rate is greater than 0.1% per day.
The composition of claim 4, wherein the third release rate occurs temporally before the second release rate.
The composition of claim 1, wherein the protein mixture comprises a bone derived protein.
The composition of claim 1, wherein the delivery system comprises nanospheres.
The composition of claim 1, further comprising a matrix.
The composition of claim 9, wherein the matrix comprises collagen.
A composition comprising:
The composition of claim 10, wherein the delivery system has a third release rate.
The composition of claim 12, wherein the third release rate is greater than 0.1% per day.
The composition of claim 12, wherein the third release rate occurs temporally before the second release rate.
The composition of claim 10, wherein the protein mixture comprises a bone derived protein.
The composition of claim 10, wherein the delivery system comprises nanospheres.
The composition of claim 10, further comprising a matrix.
The composition of claim 17, wherein the matrix comprises a material selected from the group consisting of type I collagen, type II collagen and hyaluronic acid.
The composition of claim 17, wherein the matrix comprises a material selected from the group consisting of type I collagen.
A composition comprising:
Dependencies are inferred from the claim text.