Composition and method for preparing biocompatible surfaces
OwnerSean Stucke, Ralph Chappa +2inventors
InventorsSean Stucke, Ralph Chappa, Joseph Chinn, Aron Anderson
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Abstract
The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
Claims28
A method for providing a biocompatible coating to a surface of a medical article, comprising the steps of:
- (a) irradiating a composition comprising (i) a first polymer, (ii) photoreactive groups, and (iii) a biocompatible agent selected from the group consisting of polysaccharides and polypeptides, wherein irradiating activates the photoreactive groups;
- and
- (b) after step (a), disposing the irradiated composition on the medical article.
A method for preparing a medical article having a biocompatible surface, comprising the steps of:
- (a) irradiating a composition comprising a biocompatible agent, photoreactive groups, a hydrophobic polymer, and a component selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol, polyethylene glycol sulfonates, fatty quaternary amines, fatty sulfonates, fatty acids, dextran, dextrin, and cyclodextrin, to activate the photoreactive groups;
- (b) after step (a), disposing the irradiated composition on a medical article.
A method for preparing a medical article having a surface having heparin or collagen activity comprising the steps of:
- (a) irradiating a composition comprising heparin or collagen, photoreactive groups, a first polymer that is hydrophobic, and a second polymer that is different than the first polymer;
- (b) after step (a), disposing the irradiated composition on a medical article.
Dependencies are inferred from the claim text.